英文名称
Nestin Rabbit pAb
中文名称
巢蛋白/神经上皮干细胞蛋白抗体
英文别名
ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_RAT; Nestin.
产品应用
Flow-Cyt=1μg/Test
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
交叉反应
Mouse (predicted: Rat)
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from rat Nestin: 681-750/1893
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
209 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Invasion/microenvironment > Angiogenesis
Cancer > Tumor biomarkers > Tumor antigens
Cardiovascular > Angiogenesis > Angiogenic Factors
Developmental Biology > Lineage specification > Ectoderm
Neuroscience > Cell Adhesion Proteins > Cytoskeletal Proteins > Intermediate Filaments
Neuroscience > Cell Type Marker > Neural Stem Cell marker
Neuroscience > Neurology process > Neurogenesis
Signal Transduction > Antibodies > nestin
Stem Cells > Lineage Markers > Ectoderm
Stem Cells > Neural Stem Cells > Intracellular
Stem Cells > Neural Stem Cells > Neuron Restricted Lineage
亚基
Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3.
亚细胞定位
cytoplasm
组织特异性
CNS stem cells.
翻译后修饰
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized.
相似性
Belongs to the intermediate filament family.
SWISS
P21263
Gene ID
25491
功能
Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
Entrez Gene : 10763 Human
Entrez Gene : 18008 Mouse
Entrez Gene : 25491 Rat
Omim : 600915 Human
SwissProt : P48681 Human
SwissProt : Q6P5H2 Mouse
SwissProt : P21263 Rat
Unigene : 527971 Human
Unigene : 331129 Mouse
Unigene : 9701 Rat
