英文名称
IFN gamma Rabbit pAb
中文名称
干扰素-γ/IFN-γ抗体
英文别名
IFNG; IFG; IFI; IFN Gamma; IFN Immune; IFN-gamma; IFNG; IFNG_MOUSE; Immune Interferon; Interferon gamma; Interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell Interferon; Type II Interferon.
产品应用
WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=0.5ug/Test, ICC/IF=1:50, ELISA=1:5000-10000
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
交叉反应
Human, Mouse, Rat
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human IFN gamma: 1-100/166
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
15 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Tumor immunology > Cytokines > Interferons
Immunology > Adaptive Immunity > Regulatory T Cells
Immunology > Innate Immunity > Cytokines > Interferons
Stem Cells > Signaling Pathways > TGF beta > Interferon gamma
亚基
Homodimer.
亚细胞定位
Secreted.
组织特异性
Released primarily from activated T lymphocytes.
翻译后修饰
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
疾病
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
相似性
Belongs to the type II (or gamma) interferon family.
SWISS
P01579
Gene ID
3458
功能
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
Entrez Gene : 3458 Human
Entrez Gene : 15978 Mouse
Entrez Gene : 360697 Rat
Omim : 147570 Human
SwissProt : P01579 Human
SwissProt : P01580 Mouse
Unigene : 856 Human
Unigene : 240327 Mouse
